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Symbol Name ID |
Men1
multiple endocrine neoplasia 1 MGI:1316736 |
| Darker colors indicate more annotations |
| Human Phenotypes | Diabetes mellitus |
Elevated circulating calcitonin concentration |
Elevated circulating parathyroid hormone level |
Thymoma |
Pancreatic islet cell adenoma |
Insulinoma |
Exocrine pancreatic insufficiency |
Recurrent pancreatitis |
Neoplasm of the pancreas |
Pancreatic adenocarcinoma |
Intestinal carcinoid |
Hypergastrinemia |
Elevated circulating growth hormone concentration |
Increased circulating cortisol level |
Primary hypercortisolism |
Increased serum serotonin |
Adrenocortical abnormality |
Adrenocortical adenoma |
Adrenocortical carcinoma |
Abnormal circulating aldosterone |
Increased circulating prolactin concentration |
Pituitary adenoma |
Pituitary corticotropic cell adenoma |
Pituitary gonadotropic cell adenoma |
Pituitary growth hormone cell adenoma |
Pituitary null cell adenoma |
Pituitary prolactin cell adenoma |
Pituitary thyrotropic cell adenoma |
Parathyroid adenoma |
Parathyroid carcinoma |
Parathyroid hyperplasia |
Hyperparathyroidism |
Primary hyperparathyroidism |
Goiter |
Thyroid adenoma |
Hurthle cell thyroid adenoma |
Thyroid carcinoma |
Carcinoid tumor |
Pulmonary carcinoid tumor |
Pancreatic endocrine tumor |
Glucagonoma |
Pheochromocytoma |
| Disease(s) Associated with MEN1 | ||||||||||||||||||||||||||||||||||||||||||
| hyperparathyroidism | ||||||||||||||||||||||||||||||||||||||||||
| multiple endocrine neoplasia type 1 | ||||||||||||||||||||||||||||||||||||||||||
| pancreatic cancer |
| Mouse Phenotypes | pancreas necrosis |
abnormal pancreatic acinar cell morphology |
decreased uterine NK cell number |
enlarged adrenal glands |
abnormal pancreatic islet morphology |
increased pancreatic beta cell number |
enlarged pancreatic islets |
pancreatic islet hyperplasia |
abnormal pituitary gland morphology |
enlarged pituitary gland |
enlarged parathyroid gland |
parathyroid gland hyperplasia |
thyroid gland hyperplasia |
thyroid gland cyst |
increased mammary gland tumor incidence |
increased endometrial gland number |
abnormal pancreas morphology |
pancreas cyst |
enlarged ovary |
increased Leydig cell number |
enlarged testis |
increased gland tumor incidence |
increased adrenal gland tumor incidence |
increased adrenal cortical tumor incidence |
increased adrenocortical adenoma incidence |
increased adrenal gland adenoma incidence |
increased pheochromocytoma incidence |
increased ovary tumor incidence |
increased pancreas tumor incidence |
increased pancreas adenoma incidence |
increased pancreatic islet cell adenoma incidence |
increased glucagonoma incidence |
increased insulinoma incidence |
increased pancreatic islet cell carcinoma incidence |
increased parathyroid gland tumor incidence |
increased parathyroid adenoma incidence |
increased pituitary gland tumor incidence |
increased pituitary adenohypophysis tumor incidence |
increased prolactinoma incidence |
increased pituitary adenoma incidence |
increased testis tumor incidence |
increased Leydig cell tumor incidence |
increased thyroid tumor incidence |
increased thyroid adenoma incidence |
increased thyroid carcinoma incidence |
abnormal pancreas physiology |
pancreas inflammation |
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| Availability | Mouse Genotype | |||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1.1Ctre/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1.1Gfk/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1Ctre/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1Mmey/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1Rvt/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1Zqw/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm2.1Gfk/Men1+ | ||||||||||||||||||||||||||||||||||||||||||||||||
| Men1tm1.2Ctre/Men1tm1.2Ctre Tg(PTH-cre)4167Slib/0 (conditional) |
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| Men1tm1.2Ctre/Men1tm1.2Ctre Tg(Ins2-cre)1Heed/0 (conditional) |
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| Men1tm1.2Ctre/Men1tm1.2Ctre Tg(Ins2-cre)1Dh/0 (conditional) |
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| Men1tm1.2Ctre/Men1tm1.2Ctre Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Men1tm1.2Zqw/Men1tm1.2Zqw Tg(Ins2-cre)23Herr/0 (conditional) |
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| Men1tm1.2Zqw/Men1tm1.2Zqw Pgrtm2(cre)Lyd/Pgr+ (conditional) |
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| Men1tm1Ctre/Men1tm1Ctre Tg(Pdx1-cre)89.1Dam/0 (conditional) |
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| Men1tm1Gfk/Men1tm1Gfk Tg(Ins2-cre)25Mgn/0 (conditional) |
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| Men1tm2.1Mmey/Men1tm2.1Mmey Tg(Ins2-cre)23Herr/0 (conditional) |
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| Men1tm1.2Ctre/Men1+ Tg(Ins2-cre)1Heed/0 (conditional) |
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| Men1tm1.2Ctre/Men1+ Tg(Ins2-cre)1Dh/0 (conditional) |
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| Men1tm1.2Ctre/Men1+ Tg(Ins2-cre)25Mgn/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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